AD7c-NTP biomarker for Alzheimer's disease

This article reviews the discovery and probable function of the AD7c-NTP ge ne and describes the sensitivity and specificity of assays used to detect e levated levels of the similar to 41 kD AD7c-NTP protein in cerebrospinal fl uid and urine. In addition, we present solid evidence that both the cerebro spinal fluid and urine assays for AD7c-NTP can be used as surrogate markers and diagnostic aids to detect possible or probable Alzheimer's disease. Im portantly, the AD7c-NTP assays have demonstrated value for ruling-out the d iagnosis of Alzheimer's disease and alerting caretakers to pursue other pot ential causes of dementia or cognitive impairment.