A review of septic shock

The mortality of septic shock both in percentage of septic shock cases and total number of septic shock cases, has been increasing over the past sever al decades. This is despite major advances in diagnosis and treatment. The basic cause of traumatic and septic shock has only partially been elucidate d. This review presents information about the basic cause and mechanism of septic shock as well as a new treatment based on this information. Data sou rces include research papers on the subject of septic shock from 1875 until the present. These papers numbered more than 10,000, most of which are not included in the reference list because many are duplicative. The main resu lt of rite review of literature is that all of a wide variety of treatments of septic shack have not resulted in a lowering of mortality, but in fact have increased it. Another toxin (in addition to endotoxin and its secondar ily induced host mediators) is proposed. This toxin causes disseminated int ravascular coagulation, which may obstruct the microcirculation of any and all organs, producing multiple organ failure by microclots. These microclot s may be lysed by plasminogen activator and circulation to the organs resto red.