A magnetic resonance abnormality correlating with permeability of the blood-brain barrier in a child with chemical meningitis during central nervous system prophylaxis for acute leukemia

Authors
Fukushima, T Sumazaki, R Koike, K Tsuchida, M Okada, Y Maki, T Hamano, K
Citation
T. Fukushima et al., A magnetic resonance abnormality correlating with permeability of the blood-brain barrier in a child with chemical meningitis during central nervous system prophylaxis for acute leukemia, ANN HEMATOL, 78(12), 1999, pp. 564-567
Citations number
26
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
ANNALS OF HEMATOLOGY
ISSN journal
09395555 → ACNP
Volume
78
Issue
12
Year of publication
1999
Pages
564 - 567
Database
ISI
SICI code
0939-5555(199912)78:12<564:AMRACW>2.0.ZU;2-B
Abstract
Chemical meningitis developed in a bay with acute lymphoblastic leukemia du ring central nervous system (CNS) prophylaxis. Cerebrospinal fluid examinat ion showed pleocytosis and a high protein level. There were no malignant cy tological findings. Calculated permeability of albumin across the blood-bra in barrier (BBB) was more elevated than that of immunoglobulin or alfa2-mac roglobulin. Magnetic resonance imaging(MRP) revealed diffuse pachymeningeal enhancement without any intracerebral lesion. Subsequent CNS prophylaxis w as postponed. CSF findings and BBB permeability returned to normal, correla ting well with the decrease of MRI abnormality.