Heterozygote haemoglobinopathy AS and coronary risk.

There have been several reports of vaso-occlusive events and sudden death i n subjects with sickle cell trait. However, the precise mechanism underlyin g these episodes remains unclear. The clinical observations have been suppo rted by in vitro studies in which haemoglobin AS (Hb AS) red cells showed a bnormalities of their filterability, probably related to gelling or polymer isation of the Hb AS. These in vitro studies and reports in the literature of sickle-cell hearts led the authors to investigate the possible association between AS subjects and coronary risk. The results of coronary angiography in 9 patients with Hb AS, paired with respect to the usual cardiovascular risk factors, were c ompared with those of 18 AA subjects. The number of patients who underwent coronary bypass surgery for three-vess el disease was much greater in the AS subjects. However, the difference was not statistically significant. This tendency of AS subjects to develop thrombosis and coronary artery dise ase requires further study with larger numbers of patients.