A 32-year-old man presented with multiple cranial neuropathies and his seru
m was positive for botulism type B. However, serial electrodiagnostic studi
es were consistent with a primarily neuropathic process, such as Fisher syn
drome, rather than a neuromuscular junction disorder. Electrodiagnostic stu
dy findings in patients with presumed neuromuscular junction disorders may
mimic findings suggestive of a neuropathic process, or the bioassay for bot
ulism may be falsely positive in patients with Fisher Syndrome.