Ld. Robman et al., Baseline ophthalmic findings in the vitamin E, cataract and age-related maculopathy (VECAT) study, AUS NZ J OP, 27(6), 1999, pp. 410-416
Citations number
15
Categorie Soggetti
Optalmology
Journal title
AUSTRALIAN AND NEW ZEALAND JOURNAL OF OPHTHALMOLOGY
Purpose: To describe the methodology of eye examination and the baseline ey
e characteristics or the Vitamin E, Cataract and Age-Related Maculopathy (V
ECAT) study participants
Methods: A sample of volunteers from an urban area of Melbourne, Australia,
were recruited to participate in a randomized, controlled trial investigat
ing the effect of vitamin E on the development of cataract and age-related
maculopathy. Standardized eye examinations involved clinical assessment, wh
ich included Wilmer grading of the lens, digital photography or the lens wi
th Nidek EAS-1000 lens camera and stereo photography of the macular area wi
th the Nidek 3-DX fundus camera. All cases of ophthalmic findings were dete
rmined on the basis of pathology in the worse eye.
Results: Most eyes were free from abnormalities. The most frequent findings
were cataract and age-related macular changes. Nuclear cataract (nuclear o
pacity grade greater than or equal to 2) was present in 4.5%, cortical cata
ract (cortical opacity grade greater than or equal to 2) in 14.3% and poste
rior subcapsular cataract in 3.0% of participants: in addition, coronary ca
taract was observed in 13.6%. Soft drusen larger than 125 mu m were round i
n 11.4%, retinal pigment epithelium changes in 9.5%, epiretinal membrane in
6.6% and age-related macular degeneration in 0.5% of participants.
Summary: Due to the selection criteria, the majority of participants had cl
ear or minor lens changes and/or minor retinal age-related changes. Precise
instrumental documentation will allow an accurate assessment of the incide
nce and dynamics of these changes throughout 4 years of observation.