Successful peripheral blood stem cell transplantation for myelodysplastic syndrome

Wilms' tumor (WT1) gene expression is increased in patients with leukemia a s well as myelodysplastic syndrome (MDS) and is useful for detection of min imal residual disease (MRD). A 47-year-old man given a diagnosis of refract ory anemia with excess of blasts in transformation (RAEB-T) received myeloa blative therapy followed by autologous peripheral blood stem cell transplan tation (PBSCT). MRD by WT1 expression was not detected in the graft, The pa tient has been in CR for 25 months after PBSCT. These observations suggest that PBSCT is feasible for patients with RAEB-T and analysis of WT1 express ion can be applied for patients with high risk MDS.