Miltefosine as a topical treatment for cutaneous metastases in breast carcinoma

Citation
S. Clive et al., Miltefosine as a topical treatment for cutaneous metastases in breast carcinoma, CANC CHEMOT, 44, 1999, pp. S29-S30
Citations number
4
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER CHEMOTHERAPY AND PHARMACOLOGY
ISSN journal
03445704 → ACNP
Volume
44
Year of publication
1999
Supplement
S
Pages
S29 - S30
Database
ISI
SICI code
0344-5704(199910)44:<S29:MAATTF>2.0.ZU;2-8
Abstract
Background: Recurrent cutaneous breast cancer is difficult to manage, with surgery, radiotherapy and systemic therapy all having their limitations. Mi ltefosine is a topical cytostatic agent which may provide an alternative ap proach in its treatment. Patients and methods: Patients with previously tre ated progressive cutaneous lesions from breast cancer were treated with mil tefosine on a named-patient compassionate supply basis. Miltefosine was app lied topically to the skin at a dose of 2 drops/10 cm(2) skin area. Results : Twenty-five patients were treated, most of whom had been heavily pre-trea ted. Treatment was continued for a median of 14 weeks (range 2-164). In 7 p atients grade I skin toxicities were observed, and in 4 patients grade 3 lo cal toxicities necessitated dose adjustments. A response was seen in 9 pati ents (1 complete response, 2 partial responses, 6 minor responses) giving a total response rate of 36%, with stable disease in 11 patients (44%) and p rogressive disease in 5 (20%). Those lesions which were superficial or <2 c m in diameter were most likely to respond. Conclusions: Miltefosine, either used alone or in conjunction with other therapies for distant metastases, is an effective and tolerable local treatment for cutaneous breast cancer.