The study of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel and their effects on microspheres preparation and drug release

Citation
Fl. Mi et al., The study of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel and their effects on microspheres preparation and drug release, CARBOHY POL, 41(4), 2000, pp. 389-396
Citations number
6
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE POLYMERS
ISSN journal
01448617 → ACNP
Volume
41
Issue
4
Year of publication
2000
Pages
389 - 396
Database
ISI
SICI code
0144-8617(200004)41:4<389:TSOGKA>2.0.ZU;2-0
Abstract
The effects of gelation kinetics and chain-relaxation properties of glutara ldehyde-cross-linked chitosan gel on microspheres preparation or drug relea se were studied. The rate of gelation is zero order corresponding to the ch itosan concentration but non-zero order corresponding to the glutaraldehyde concentration. It was suggested that the cross-linking reaction was mainly dominated by the concentration of small molecule reactant, glutaraldehyde. The relaxation of an entangled polymer chain in a gel network as a result of the swelling of cross-linked chitosan hydrogel was investigated by the s tress-strain determination. The higher the cross-linking density of chitosa n hydrogel, the lower the swelling ability of chitosan hydrogel due to the slower relaxation rate of polymer chain, which then results in the decrease d drug-release rate. (C) 2000 Elsevier Science Ltd. All rights reserved.