Adenovirus infections in hematopoietic stem cell transplant recipients

We report a 12% incidence of adenovirus infections among 532 recipients of hematopoietic stem cell transplant (HSCT) from January 1986 through March 1 997. The median time from day of stem cell infusion to first positive cultu re was 41 days. Recipients of allogeneic seem cells, as opposed to autologo us stem cell recipients, were more likely to have a culture positive for ad enovirus (16% vs. 3%; P<.0001). Pediatric patients were also more: likely t han adults to have a positive culture (23% vs. 9%; P<.0001), Among stem cel l recipients with partially matched related donors, pediatric recipients ap pear to be at significantly greater risk for infection than adult recipient s (P<.001). Positive cultures were associated with evidence of invasion in 64% of cases (41 of 64), A multiple logistic regression analysis showed tha t isolating adenovirus from more than 1 site correlated with greater risk f or invasive infections (P=.002). Invasive infections were associated with p oorer chance of survival.