Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52

Authors
Carim, L Sumoy, L Nadal, M Estivill, X Escarceller, M
Citation
L. Carim et al., Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52, CYTOG C GEN, 87(1-2), 1999, pp. 85-88
Citations number
11
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
87
Issue
1-2
Year of publication
1999
Pages
85 - 88
Database
ISI
SICI code
0301-0171(1999)87:1-2<85:CEAMOP>2.0.ZU;2-#
Abstract
We report the sequence, tissue distribution, and chromosome location of a n ovel gene, PDCD9 (programmed cell death 9). PDCD9 is the mammalian counterp art of the Gallus gallus pro-apoptotic protein p52. The human cDNA has an o pen reading frame of 1,314 nucleotides and was predicted to encode a protei n of 438 amino acids with a calculated mass of 50 kDa. The protein sequence s of chicken, mouse, and human PDCD9 are remarkably conserved. PDCD9 mRNA i s expressed ubiquitously in adult tissues, displaying a stronger signal in heart, skeletal muscle, kidney, and liver. PDCD9 was mapped to chromosome 5 q11. Copyright (C) 1999 S. Karger AG, Basel.