cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH

Authors
Adams, JC Zhang, L
Citation
Jc. Adams et L. Zhang, cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH, CYTOG C GEN, 87(1-2), 1999, pp. 19-21
Citations number
12
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
87
Issue
1-2
Year of publication
1999
Pages
19 - 21
Database
ISI
SICI code
0301-0171(1999)87:1-2<19:CCOHMA>2.0.ZU;2-X
Abstract
Muskelin is a novel intracellular protein, identified in mouse cells, that acts as a mediator of cell spreading and cytoskeletal responses to the extr acellular matrix component thrombospondin-1. We report that human muskelin is 98% identical with mouse muskelin at the amino acid level. The human mus kelin gene is located at 7q32. The mouse muskelin gene maps syntenically at chromosome 6 B1/B2. Copyright (C) 1999 S. Karger AG, Basel.