The use of a hydrophobic matrix for the sustained release of a highly water soluble drug

Authors
Martini, LG Coles, M Gravell, K Stephenson, S Thomson, CM
Citation
Lg. Martini et al., The use of a hydrophobic matrix for the sustained release of a highly water soluble drug, DRUG DEV IN, 26(1), 1999, pp. 79-83
Citations number
7
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN journal
03639045 → ACNP
Volume
26
Issue
1
Year of publication
1999
Pages
79 - 83
Database
ISI
SICI code
0363-9045(1999)26:1<79:TUOAHM>2.0.ZU;2-O
Abstract
An experimental investigation into the use of a hydrophobic matrix to contr ol the release of a highly water soluble drug was undertaken. Matrices cons isting of hydrogenated vegetable oil and calcium sulfate with a 4% drug loa ding showed a sustained-release profile of up to 24 hr. The release mechani sm from such matrices seemed to obey both root time kinetics and first-orde r behavior. Investigations showed that the effect of geometry had a signifi cant effect on the drug release rate.