Mapping of the beige (bg) Gene on Rat Chromosome 17

Authors
Nishikawa, T Nishimura, M
Citation
T. Nishikawa et M. Nishimura, Mapping of the beige (bg) Gene on Rat Chromosome 17, EXP ANIM, 49(1), 2000, pp. 43-45
Citations number
16
Categorie Soggetti
Animal Sciences
Journal title
EXPERIMENTAL ANIMALS
ISSN journal
13411357 → ACNP
Volume
49
Issue
1
Year of publication
2000
Pages
43 - 45
Database
ISI
SICI code
1341-1357(200001)49:1<43:MOTB(G>2.0.ZU;2-8
Abstract
The rat beige (bg) autosomal recessive gene, causing Chediak-Higashi Syndro me (CHS) in rat, was mapped on Chr 17 by using synteny of rat to mouse and humans. The linkage between the beige gene and PCR-amplified microsatellite markers in (DA-bg x BN)F-1 x DA-bg backcross progeny was analysed. The rec ombination frequency was 9.5% between Prl and Acrm and 19.1% between Acrm a nd bg. The proposed order of three genes is PrI-Acrm-bg. This rat bg gene w as confirmed to be homologus to the beige (bg) gene of mouse located on Chr 13 and the CHS (Lyst) gene of man located on Chr 1 (1q43).