Associations among dust exposure, smoking habits, and demographic fact
ors and longitudinal changes of lung function were assessed among male
steel workers, Cohort descriptive data analysis was conducted in 541
steel workers who had performed spirometry at least twice between 1982
and 1991 (mean follow-up, 6.1 years). The annual change (slope) in FV
C, FEV1, FEV1/FVC%, and in body weight was determined by simple linear
regression. The Pearson correlation coefficient between weight change
and spirometry changes was calculated. Comparisons were also done in
75 pairs of steel workers matched by age, height, initial FEV1, and sm
oking status, but whose FEV1 declines differed by greater than or equa
l to 60 mL/yr. The FEV1 and FVC declined an average of 44 and 50 mL/yr
, respectively, for the cohort as a whole. The FEV1 and FVC declined 5
2 and 54 mL/yr for current smokers, 43 and 53 mL/yr for ex-smokers, an
d 36 and 43 mL/yr for nonsmokers, respectively. Increasing weight was
highly correlated with accelerated decline in lung function (p < 0.000
1). In the matched pairs, mean slopes for FVC, FEV1, and FEV1/FVC rati
o were -96 mL/yr, -95 mL/yr, and -0.40%/yr for the rapid decliners; an
d +5 mL/yr, +10 mL/yr, and +0.10%/yr for their partners (p < 0.0001),
Matched pair comparisons showed that the rapid decliners averaged a 4.
313 kg weight gain, while their partners gained 1.044 kg during the fo
llow-up period, The slope of weight gain was 0.708 kg/yr for rapid dec
liners and 0.191 kg/yr for comparison workers (p < 0.0036), Weight gai
n, in addition to aging and cigarette smoking, was found to be associa
ted with the longitudinal rate of decline in FVC, FEV1, and FEV1/FVC r
atio.