Four new styryllactones, leiocarpin A (1), 7-epi-goniodiol (2), leiocarpin
B (3) and leiocarpin C (4), respectively, were isolated from the stem bark
of Goniothalamus leiocarpus. Their structures were elucidated by means of s
pectral method. The relative configurations of 1, 2 and 3 were determined b
y X-Ray crystallographic analysis. Compounds 2 and 3 possess antitumor acti
vities.