M. Biggiogera et al., Terminal differentiation of erythroblasts leads to RNP segregation and formation of heterogeneous ectopic RNP-derived structures, HISTOCHEM C, 112(6), 1999, pp. 473-477
We show an as yet unnoticed feature of mammalian erythrocyte maturation, i.
e., the formation of heterogeneous ectopic RNP-derived structures in the nu
cleus of erythroblasts, occurring in parallel with chromatin condensation.
Inside these structures, RNPs are always recognized by specific antibodies,
which demonstrates that the protein moieties of RNPs still preserve (at le
ast partially) their native organization. This phenomenon shares extensive
similarity with the segregation and clustering of nuclear RNPs occurring du
ring spontaneous apoptosis of rat thymocytes and in several other cell mode
ls in which transcription is physiologically arrested.