M. Eneroth et al., IMPROVED WOUND-HEALING IN TRANSTIBIAL AMPUTEES RECEIVING SUPPLEMENTARY NUTRITION, International orthopaedics, 21(2), 1997, pp. 104-108
The objective of this prospective study of matched controls was to fin
d out whether supplementary nutrition would improve wound healing and
decrease mortality in patients undergoing transtibial amputation for o
cclusive arterial disease. The nutritional status of 32 consecutive tr
anstibial amputees was assessed and 28 were classified as malnourished
. Supplementary nutrition was given reaching an average intake of 2098
kcal/day for a total of II days. In 24 patients, at least 5 days preo
perative supplementary nutrition were given, followed by postoperative
treatment for a total of II days. Four patients who had an immediate
operation were given only postoperative treatment, and 4 were excluded
The controls were 32 amputees in another hospital and matching proced
ures were carried out with corrections for diabetes, sex, age, smoking
habits, previous vascular surgery and living conditions before amputa
tion. Healing, including those healed before death in both groups, occ
urred in 26 of the nutrition group compared to 13 in the control group
, which was statistically significant. Nine patients died within 6 mon
ths in the nutrition group compared to 14 of the controls (not signifi
cant). Malnutrition was present in nearly 90% of transtibial amputees
and supplementary nutrition improved healing, but not mortality.