The protective effects of meniscal transplantation on cartilage - An experimental study in sheep

Background Meniscal loss may result in arthritis. The aim of this study was to establish a simple operative method for meniscal transplantation in a l arge animal model and to determine whether meniscal transplantation provide s protection of the articular surfaces,,whether meniscal allografts have th e same protective effect as meniscal autogenous grafts, and whether there i s any rejection phenomenon associated with meniscal allografts. Methods: Twenty-eight sheep were divided into four study groups, which were treated with (I) a sham operation (four sheep), (2) a meniscectomy (eight sheep), (3) a meniscal autogenous graft (eight sheep), or (4) a meniscal al lograft (eight sheep). The meniscal transplant was secured with three sutur e anchors to the tibia, At four months after the operation, macroscopic and microscopic evaluations of the articular cartilage and the menisci of the sheep knees were performed in st blinded fashion. Results: The group treated,vith the sham operation had no cartilage damage and had normal meniscal tissue. The meniscectomies resulted in significant macroscopic and microscopic damage to the articular cartilage in the medial compartment, The mean score land standard error of the mean) for macroscop ic damage to the cartilage in the group treated with the meniscectomy was 6 .5 +/- 0.8 points compared with 3.9 +/- 0.7 points in the group treated wit h the autogenous graft and 4.3 +/- 0.6 points in the group treated with the allograft (p < 0.05), The size of the area of damaged articular cartilage was reduced by approximately 50 percent in both groups treated with a menis cal transplant compared with the group treated with the meniscectomy (p < 0 .05), There were no significant differences between the group treated with the autogenous graft and that treated with the allograft, The histological appearance of the meniscal autogenous grafts was within normal limits. Inte restingly; all of the allografts had evidence of fibrinoid degeneration wit h areas of hypocellularity and cloning of chondroid cells, Conclusions: These results suggest that meniscal transplantation provides n oticeable although not complete protection against damage to the articular cartilage after a meniscectomy, The meniscal allografts were just as effect ive in providing this protection as were the meniscal autogenous grafts. Clinical Relevance: If these results are applicable to humans, they would s upport the transplantation of meniscal allografts, but it may be necessary to pay special attention to isometricity of meniscal grafts.