Additional human papillomavirus types detected by the hybrid capture tube test among samples from women with cytological and colposcopical atypia

The type specificity of the human papillomavirus (HPV) Hybrid Capture Tube (HCT) test was evaluated by using typing with PCR (MY09-MY11)-restriction f ragment length polymorphism (RFLP) and sequencing.;UI samples HCT test posi tive for only low-risk HPV (n = 15) or only high-risk HPV (n = 102) were co nfirmed, whereas 9 of 12 HCT test double-positive samples contained only hi gh-risk HPV types as determined by PCR-RFLP. Several high-risk HPV types (H PV-53, -58, -62, -66, -CP8303, and -MM4) not included in the HCT test Here indeed detected, indicating a broader detection range dth retained distinct ion between low-risk and high-risk HPV types.