CD40-CD40 ligand

Citation
C. Van Kooten et J. Banchereau, CD40-CD40 ligand, J LEUK BIOL, 67(1), 2000, pp. 2-17
Citations number
128
Categorie Soggetti
Immunology
Journal title
JOURNAL OF LEUKOCYTE BIOLOGY
ISSN journal
07415400 → ACNP
Volume
67
Issue
1
Year of publication
2000
Pages
2 - 17
Database
ISI
SICI code
0741-5400(200001)67:1<2:CL>2.0.ZU;2-L
Abstract
CD40 is a cell surface receptor that belongs to the tamar necrosis factor-I l (TNF-R) family, and that was first identified and functionally characteri zed on B lymphocytes, Its critical role in T cell-dependent humoral immune responses was demonstrated by patients,vith the hyper-IgM syndrome, as well as by gene targeting in mice. However, in recent years it has become dear that CD40 is expressed much more Broadly, including expression on monocytes , dendritic cells, endothelial cells, and epithelial cells. In addition, th e CD40-ligand (CD40-L/CD154), a member of the TNF family, is also expressed more widely than activated CD4(+) T cells only. Therefore it is now though t that CD40-CD40-L interactions play a more general role in immune regulati on. Collectively these studies have culminated in pre-clinical and clinical studies that are in progress, This article reviews recent developments in this field of research, with main emphasis on (T) structure and expression of CD40 and its ligand; (2) CD40 signal transduction; (3) in vitro function of CD40 on different cell types; and (4) in vivo functions of CD40/CD40-L interactions.