Prenatal and perinatal risk factors for autism

Aim: To identify pre- and perinatal risk factors for autism. Method: Case control study. We matched names of patients from North Dakota who met DSM criteria for autism, a pervasive developmental disorder, and au tistic disorder with their birth certificates. Five matched controls were s elected for each case. Results: Univariate analysis of the 78 cases and 390 controls identified se ven risk factors. Logistic modeling to control for confounding produced a f ive variable model. The model parameters were chi(2) = 36.6 and p < 0.001. The five variables in the model were decreased birth weight, low maternal e ducation, later start of prenatal care, and having a previous termination o f pregnancy. Increasing father's age was associated with increased risk of autism. Conclusion: This methodology may provide an inexpensive method for clinics and public health providers to identify risk factors and to identify matern al characteristics of patients with mental illness and developmental disord ers.