Systemic arterial pressure is determined by a complex interaction between t
he general control of the circulation and locally acting mechanisms which s
erve the local demands of the vascular region. The general control can be s
tudied by measuring fluctuations in the systemic mean arterial blood pressu
re (sysMAP) and cardiac output. Specific mechanisms, characterizing a given
vascular region, can be studied by measuring local blood pressure simultan
eously with sysMAP, By comparing these two signals the activity of local me
chanisms can be elucidated. The present work was aimed at studying the char
acteristics of tone regulation in the mesenteric vascular bed. Recently, a
new technique was developed for recording the mean intravascular pressure a
t the base of the mesenteric arcade (mesMAP; at the point where the arcade
runs closest to the intestinal wall) in conscious, unrestrained rats [1, 2]
, This technique showed that, in the rat mesenteric vascular bed, arteries
proximal to the mesenteric arcade (with diameter of >200 mu m) contribute s
ubstantially to the control of peripheral resistance, In the present study
we applied this approach for the investigation of short-term blood pressure
variability. This allowed us to observe regular oscillations of mesenteric
vascular tone, probably resulting from vasomotion-like vessel activity.