Interleukin-8 - An early marker for bacterial infection

The cytokine network is activated in the pathogenetic mechanisms of septic diseases, We measured serum concentrations of interleukin-8 (IL-8) in 152 p atients with septic syndrome and 25 control subjects, IL-8 concentration in patients with septic syndrome was significantly (P<.05) higher than in con trols. Se-rum IL-8 concentration was assayed prospectively in 6 patients un dergoing chemotherapy for leukemia. Increased IL-8 concentration preceded o nset of fever and elevation of C-reactive protein by 1 day, Human periphera l whole blood cells were stimulated with phorbol 12-myristate 13-acetate (P MA), lipopolysaccharide (LPS), or lipoteichoic acid, IL-8 mRNA expression w as detected 10 minutes after PMA or LPS exposure, and IL-8 was secreted int o culture media 3 hours after exposure, These data suggest that IL-8 is a u seful early indicator of bacterial infection.