Aminolaevulinic acid-induced photodynamic therapy in the treatment of dysplastic Barrett's oesophagus and adenocarcinoma

Citation
R. Ackroyd et al., Aminolaevulinic acid-induced photodynamic therapy in the treatment of dysplastic Barrett's oesophagus and adenocarcinoma, LASER MED S, 14(4), 1999, pp. 278-285
Citations number
39
Categorie Soggetti
Surgery,"Medical Research Diagnosis & Treatment
Journal title
LASERS IN MEDICAL SCIENCE
ISSN journal
02688921 → ACNP
Volume
14
Issue
4
Year of publication
1999
Pages
278 - 285
Database
ISI
SICI code
0268-8921(1999)14:4<278:AAPTIT>2.0.ZU;2-X
Abstract
Photodynamic therapy (PDT) may have a role in the prevention of oesophageal cancer. Ten patients with Barrett's oesophagus, three with law-grade dyspl asia (LGD), four with high-grade dysplasia (HGD), one with carcinoma in sit u and two with invasive carcinoma, were treated with PDT. All received 30 m g/kg aminolaevulinic acid (ALA) followed 4 h later by laser endoscopy. Half were treated with red light (630 nm; 100 mW/cm(2) for 1000 s) and half wit h green light (514 nm; 100 mW/cm(2) for 500 s). Columnar epithelial regress ion was seen in all patients with dysplasia (mean area decrease 44%; range 10-100%), with apparent elimination of dysplasia in all cases. In patients with in situ or invasive carcinoma, no response was seen. ALA-induced PDT, using either red or green light, produces effective ablation of dysplastic Barrett's oesophagus, hence may have a role in the prevention of oesophagea l carcinoma, but has little effect on in situ or invasive adenocarcinoma.