Objective. Many studies suggest that impaired health states are valued more
positively when experienced than when hypothetical. This study investigate
d to what extent this discrepancy occurs and examined four possible explana
tions: non-corresponding description of the hypothetical health state, new
understanding due to experience with the health state, valuation shift due
to a new status quo, and instability of preference. Patients and methods. F
ifty-five breast cancer patients evaluated their actually experienced healt
h state, a radiotherapy scenario, and a chemotherapy control scenario befor
e, during, and after postoperative radiotherapy. Utilities were elicited by
means of a visual analog scale (VAS), a chained time tradeoff (TTO), and a
chained standard gamble (SG). Results. The discrepancy was found for all m
ethods and was statistically significant for the TTO (predicted utilities:
0.89, actual utilities: 0.92, p less than or equal to 0.05). During radioth
erapy, significant differences (p less than or equal to 0.01) were found be
tween the utilities for the radiotherapy scenario and the actual health sta
te by means of the VAS and the SG, suggesting non-corresponding description
as an explanation. The utilities of the radiotherapy scenario and the chem
otherapy control scenario remained stable over time, and thus new understan
ding, valuation shift, and instability could be ruled out as explanations.
Conclusion. Utilities obtained through hypothetical scenarios may not be va
lid predictors of the value judgments of actually experienced health states
. The discrepancy in this study seems to have been due to differences betwe
en the situations in question (non-corresponding descriptions).