T. Pajpanova et al., Effects of newly synthesized analogs of MIF-1 containing unnatural amino acids on electrically evoked smooth muscle contractions, METH FIND E, 21(9), 1999, pp. 591-594
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
New MIF-I (Pro-Leu-Gly-NH2) analogs containing unnatural amino acids such a
s L-canavanine (Cav) and L-cysteic acid S-(2-aminoethyl)amide (sLys) have b
een synthesized and in vitro experiments were performed to study their acti
on on neurotransmission in target tissues with adrenergic and cholinergic n
eurotransmission. The experiments were carried out on electrically stimulat
ed proximal guinea pig ileum (GPI) and the prostatic part of rat and rabbit
vasa deferentia (VDR, VDRaBB). The present results show that the newly syn
thesized Cav(2)-MIF and sLys(2)-MIF might affect electrically evoked smooth
muscle contractions. (C) 1999 Prous Science. All rights reserved.