Relating axonal injury to functional recovery in MS

A patient was followed after the new onset of hemiparesis from relapse of M S with serial MR spectroscopy and functional MRI. The association of clinic al improvement with recovery of N-acetylaspartate, a marker of neuronal int egrity, and progressive reduction of abnormally large functional MRI cortic al activation with movement demonstrates that dynamic reorganization of the motor cortex accompanies remission of MS.