Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: A population-based study of African Americans

Authors
Evans, RM Emsley, CL Gao, S Sahota, A Hall, KS Farlow, MR Hendrie, H
Citation
Rm. Evans et al., Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: A population-based study of African Americans, NEUROLOGY, 54(1), 2000, pp. 240-242
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
54
Issue
1
Year of publication
2000
Pages
240 - 242
Database
ISI
SICI code
0028-3878(20000111)54:1<240:SCAGAT>2.0.ZU;2-R
Abstract
A significant interaction among total serum cholesterol (TC), APOE genotype , and AD risk was found in a population-based study of elderly African Amer icans. Increasing TC was associated with increased AD risk in the group wit h no epsilon 4 alleles, whereas TC was not associated with increased AD ris k in the group with one or more epsilon 4 alleles. Further study of the rel ationship between cholesterol and APOE genotype is needed to confirm this a ssociation, but the results suggest that cholesterol may be a potentially m odifiable environmental risk factor for AD.