MRI study of human brain exposed to dose repetitive magnetic stimulation of visual carter

T1-, T2-, and diffusion-weighted MRI was used to determine whether repetiti ve transcranial magnetic stimulation (rTMS) affects the blood-brain barrier or induces localized brain edema. In 11 healthy individuals, 1,200 to 3,80 0 stimuli were applied over the visual cortex of one hemisphere in series o f 5-, 10-, or 20-Hz stimulus trains. MRI performed 6 minutes to 6 hours aft er rTMS did not show pathologic changes in conventional MRI sequences, afte r application of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), or by determining apparent diffusion coefficients.