Conjunctival lymphocytic infiltrates associated with Epstein-Barr virus

Purpose: To describe the clinicopathologic features of two patients with Ep stein-Barr virus (EBV) associated conjunctival lymphocytic infiltrates. Design: Two case reports. Methods: The clinical histories and pathologic findings of two patients wit h salmon-colored conjunctival infiltrates are described. Main Outcome Measurements: Clinical observation and pathologic examination of conjunctival biopsy specimens with accompanying immunohistochemical stai ning, flow cytometric immunophenotyping, and polymerase chain reaction anal ysis when appropriate. Results: One patient had ipsilateral preauricular lymphadenopathy, elevated serum EBV titers, and a unilateral reactive lymphocytic infiltrate resulti ng in a conjunctival mass. The other patient had bilateral conjunctival lym phocytic infiltrates causing conjunctival masses. There was an expanded clo nal population of B lymphocytes in the conjunctival mass in the second pati ent. Both patients had EBV antigen in their conjunctival lymphocytic infilt rates. Conclusions: Conjunctival lymphocytic lesions associated with EBV represent a spectrum of reactive infiltrates to monoclonal populations. Ophthalmolog y 2000;107:159-163 (C) 2000 by the American Academy of Ophthalmology.