Basal cell adenocarcinoma of the lacrimal gland

Purpose: Basal cell adenocarcinoma is a recently recognized entity among ma lignant tumors of the salivary glands. This entity has not received enough attention among ophthalmologists and ophthalmic pathologists. We recommend that basal cell adenocarcinoma be included in the differential diagnosis of lacrimal gland tumors. Design: Case report. Methods: In 1988 a lacrimal gland tumor was incompletely removed from the l eft orbit of a 36-year-old woman and diagnosed as "solid basaloid adenoid c ystic carcinoma". Soon after, an exenteration of the orbit was performed. I n 1998, upon review of the initial histopathology, the diagnosis of solid a denoid cystic carcinoma was changed to basal cell adenocarcinoma. Results and Main Outcome Measure: The pathologic findings included nests of basaloid cells with minimal atypia and incomplete palisading around the pe riphery. The cells were of two types. The first type were large, pale cells with round or oval nuclei, scanty cytoplasm, and ill-defined borders. The other type were smaller cells with hyperchromatic nuclei situated mainly ne ar the periphery of the nests. There was no necrosis or perineural invasion . Mitotic figures were present. Cysts within the nests showed Alcian blue n egative contents. Immunohistochemistry showed a positive reaction to cytoke ratin and a negative reaction with smooth muscle actin (SMA). Conclusions: The Alcian blue negative stain, the negative reaction to SMA, and the fact that the patient is still alive 10 years after exenteration fa vored the diagnosis of basal cell adenocarcinoma. It is essential to differ entiate a basal cell adenocarcinoma of the lacrimal gland from the solid ba saloid type of adenoid cystic carcinoma, because the former has a better pr ognosis. Patients with basal cell adenocarcinomas of the lacrimal gland sho uld be closely monitored for local recurrences because this tumor has the t endency to show perineural invasion. Ophthalmology 2000;107:164-168 (C) 200 0 by the American Academy of Ophthalmology.