Tirucallane triterpenes from Dysoxylum macranthum

Authors
Mohamad, K Martin, MT Litaudon, M Gaspard, C Sevenet, T Pais, M
Citation
K. Mohamad et al., Tirucallane triterpenes from Dysoxylum macranthum, PHYTOCHEM, 52(8), 1999, pp. 1461-1468
Citations number
20
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
52
Issue
8
Year of publication
1999
Pages
1461 - 1468
Database
ISI
SICI code
0031-9422(199912)52:8<1461:TTFDM>2.0.ZU;2-U
Abstract
Eleven new tirucallane-type triterpenes, dymacrins A-K, were isolated from the bark of Dysoxylum macranthum together with two known tetracyclic triter penes and two known pregnane steroids. The structures of the new compounds were determined by spectral means, essentially 2D NMR experiments. Dymacrin s B, C, H and J showed moderate cytotoxicity against KB cells (IC50 5.6, 5. 0, 8.3 and 1.0 mu g/ml, respectively). (C) 1999 Elsevier Science Ltd. All r ights reserved.