Eleven new tirucallane-type triterpenes, dymacrins A-K, were isolated from
the bark of Dysoxylum macranthum together with two known tetracyclic triter
penes and two known pregnane steroids. The structures of the new compounds
were determined by spectral means, essentially 2D NMR experiments. Dymacrin
s B, C, H and J showed moderate cytotoxicity against KB cells (IC50 5.6, 5.
0, 8.3 and 1.0 mu g/ml, respectively). (C) 1999 Elsevier Science Ltd. All r
ights reserved.