From the fruits of Vitex agnus-castus L. one new diterpene, 6 beta,7 beta-d
iacetoxy-13-hydroxy-labda-8,14-diene, as well as two previously described d
iterpenes (rotundifuran and vitexilactone) were isolated. All obtained dite
rpenoids belong to the labdane typ. The structures determinations were main
ly based on 1D and 2D NMR spectra and MS data interpretation. 6 beta,7 beta
-diacetoxy-13-hydroxy-labda-8,14-diene and rotundifuran showed an affinity
to the dopamine-D-2-receptor. (C) 1999 Elsevier Science Ltd. All rights res
erved.