Sesquiterpene lactones and bisbibenzyl derivatives from the neotropical liverwort Frullania convoluta

The new germacranolide epi-isocostunolide and two new bisbibenzyls, 2'-(11- hydroxy-1-bibenzyl-oxy)-1'-methoxy-6',10',11'- trihydroxy-7',8'-dihydro-phe nanthrene and 2'-(10,11-dihydroxy-1-bibenzyi-oxy)-1'-methoxy-6',10',11'-tri hydroxy-7',8'-dihydrophenanthrene, along with the known eudesmanolides, alp ha-cyclocostunolide, brothenolide, nepalensolide A and nepalensolide B, the bisbibenzyls, perrottetin E, perrottetin F, perrottetin G, 7',8'-dehydrope rrottetin F, and the bibenzyls, lunularic acid and lunularin, have been iso lated from the neotropical liverwort Frullania convoluta. Their structures were elucidated by NMR spectroscopy. (C) 1999 Elsevier Science Ltd. All rig hts reserved.