Cyclopeptide alkaloids from Heisteria nitida

Integerrenine, and a new cyclopeptide alkaloid, containing the unusual amin e oxide function, anorldianine 27-N oxide, stigmasterol, beta-sitosterol, l upeol, (+)-catechin, (-)-epicatechin and 4-hydroxy-2-methoxy benzoic acid w ere isolated from the Ecuadorian medicinal plant Heisteria nitida (Engl.), Olacaceae. The structures were determined by UV, IR, NMR and mass spectrosc opic investigations and chemical transformations. The cyclopeptide alkaloid s have been isolated and characterized for the first time in the family Ola caceae. (C) 1999 Elsevier Science Ltd. All rights reserved.