Goniothalamusin, a linear acetogenin from Goniothalamus gardneri

A new acetogenin, trivial name goniothalamusin, has been isolated from the aerial parts of Goniothalamus gardneri (Annonaceae). Goniothalamusin is a l inear acetylenic and olefinic acetogenin with a C25 skeleton, lacking oxyge nated substituents on its alkyl chain and with a new type of saturated gamm a-hydroxymethyl-gamma-lactone terminal ring. Its structure and relative ste reochemistry established as rel-24 alpha-hydroxymethyl-2 beta-eicosa-21-en- 13-yn-tetrahydrofuran-1-one has been elucidated by spectroscopic analysis. (C) 1999 Elsevier Science Ltd. All rights reserved.