Effects of prostaglandin E-1 on high density lipoprotein-phospholipid composition

Serum high-density phospholipids (HDL-phospholipids) composition was determ ined in rats treated with prostaglandin E-1 (PGE(1)) and control group trea ted with isotonic saline. Total phospholipids and HDL-phospholipids levels at serum were found lower in rats treated with PGE(1), than in controls. Co nsidering the individual phospholipid classes of HDL, we observed that phos phatidylocholine (PC), phosphatidylinositol (PI) and diphosphatidylglycerol (DPG) serum concentrations were significantly higher in treated rats than in controls (P<0.001, P<0.005 and P<0.05 respectively). Furthermore, the se rum concentrations of lysophosphatidylocholine (LPC) and phosphatidylserine (PS) were significantly lower in treated rats than in controls (P<0.01 and P<0.001 respectively). These findings suggest that PGE, influences the com position of HDL-phospholipids and possibly modifies their action on lipid m etabolism. (C)1999 Harcourt Publishers Ltd.