Jj. Broerse et al., Assessment of a carcinogenic risk for treatment of Graves' ophthalmopathy in dependence on age and irradiation geometry, RADIOTH ONC, 53(3), 1999, pp. 205-208
Citations number
18
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
In view of the probable carcinogenic risk due to the irradiation of Graves'
ophthalmopathy in young patients the effective dose was assessed for two g
eometries, Adjusting the field to the conical outline of the orbit resulted
in appreciable reduction in dose to uninvolved areas such as brain and bon
e marrow. In Leiden and in Essen the initial target dose was 20 Gy in 10 fr
actions of 2 Gy. Since 1996 the target dose in Essen was lowered to 10 frac
tions of 1.6 Gy with equal positive results. The combined effect of field o
ptimization and 20% reduction in target dose has lowered the effective dose
from 65 to 34 mSv, The attributable lifetime risk for fatal malignancies o
f 0.3% as a population average will be considerably reduced when the exposu
re occurs at older age. (C) 1999 Elsevier Science Ireland Ltd. All rights r
eserved.