First enantioselective synthesis of manoalide: application of aldehyde-dioxinone enantioselective condensation

Authors
Soriente, A De Rosa, M Apicella, A Scettri, A Sodano, G
Citation
A. Soriente et al., First enantioselective synthesis of manoalide: application of aldehyde-dioxinone enantioselective condensation, TETRAHEDR-A, 10(23), 1999, pp. 4481-4484
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
23
Year of publication
1999
Pages
4481 - 4484
Database
ISI
SICI code
0957-4166(199912)10:23<4481:FESOMA>2.0.ZU;2-8
Abstract
Manoalide, an analgesic and anti-inflammatory sesterterpene, has been stere oselectively synthesized for the first time. The C-4 stereogenic centre has been introduced in an early step by enantioselective aldol condensation us ing a Ti(OiPr)(4)/(R)-(+)-binol complex. (C) 1999 Elsevier Science Ltd. All rights reserved.