Failure to empty the urinary bladder completely can be attributed to failur
e of detrusor contractile function, inappropriate outlet resistance, or bot
h. For each of these mechanisms, anatomic, neurogenic, and end-organ (myoge
nic or idiopathic) abnormalities are possible. The approach to urinary rete
ntion involves systematic consideration of neurogenic, obstructive, and fun
ctional causes and requires understanding of the neurophysiology and pharma
cology of micturation.