Urinary tract infection: a moving target

Urinary tract infection is an old problem that continues to present new cha llenges. The purpose of this special edition is to pull together new basic scientific information regarding the pathogenesis of infection and to revie w the state of the art in the evaluation and treatment of urinary tract inf ection in some of the more complex or challenging clinical settings. The go al has been more than a summarization of current knowledge, the intent has been to highlight areas of uncertainty, thereby emphasizing the need for fu rther investigation. Herein we briefly mention four clinical settings for u rinary tract infection that, in our opinion, present important new or evolv ing challenges and are particularly fertile areas for further work.