Cholesterol-lowering effects of psyllium intake adjunctive to diet therapyin men and women with hypercholesterolemia: meta-analysis of 8 controlled trials
Jw. Anderson et al., Cholesterol-lowering effects of psyllium intake adjunctive to diet therapyin men and women with hypercholesterolemia: meta-analysis of 8 controlled trials, AM J CLIN N, 71(2), 2000, pp. 472-479
Background: Soluble fibers, including those from psyllium husk, have been s
hown to augment the cholesterol-lowering effects of a low-fat diet in perso
ns with hypercholesterolemia. As evidence of this, the US Food and Drug Adm
inistration recently authorized the use of health claims on food products c
ontaining soluble fiber from psyllium that state that they are associated w
ith a decreased risk of coronary heart disease. Objective: This meta-analys
is was conducted to more precisely define the hypolipidemic effects and saf
ety of psyllium when used adjunctive to a low-fat diet in men and women wit
h hypercholesterolemia.
Design: The 8 studies in the meta-analysis included a total of 384 and 272
subjects receiving psyllium or cellulose placebo, respectively. All studies
evaluated the hypocholesterolemic effects of 10.2 g psyllium/d adjunctive
to a low-fat diet for greater than or equal to 8 wk in individuals with mil
d-to-moderate hypercholesterolemia after a low-fat diet lead-in phase lasti
ng greater than or equal to 8 wk. The safety and adverse events associated
with psyllium consumption were summarized from pooled data of 19 clinical s
tudies ranging from 6 wk to 6 mo in duration.
Results: Consumption of 10.2 g psyllium/d lowered serum total cholesterol b
y 4% (P < 0.0001), LDL cholesterol by 7% (P < 0.0001), and the ratio of apo
lipoprotein (apo) B to apo A-I by 6% (P < 0.05) relative to placebo in subj
ects already consuming a low-fat diet, with no effect on serum HDL or triac
yl-glycerol concentrations.
Conclusions: Psyllium supplementation significantly lowered serum total and
LDL-cholesterol concentrations in subjects consuming a low-fat diet. Psyll
ium is well tolerated and safe when used adjunctive to a low-fat diet in in
dividuals with mild-to-moderate hypercholesterolemia.