Peek-a-boo fragile site at 16D associated with Tourette syndrome, bipolar disorder, autistic disorder, and mental retardation

Five patients with a fragile site at 16q22-23 and neuropsychiatric disorder s are reported. Three of five had Tourette disorder, three had mental retar dation, two had bipolar disorder, and one had autistic disorder. During our attempts to study the fragile sites in more detail we were unable to repro duce the fragile sites found several years earlier. The potential relations hip between the fragile sites and the neuropsychiatric disorders in these p atients is discussed. Am. J, Med, Genet. (Neuropsychiatr. Genet.) 96:69-73, 2000, (C) 2000 Wiley-Liss, Inc.