Three sibs diagnosed prenatally with situs inversus totalis, renal and pancreatic dysplasia, and cysts

Recently we described a previously apparently undescribed autosomal recessi ve syndrome in two sib fetuses with situs inversus totalis, cystic dysplast ic kidneys and pancreas, bowing of the lower limbs and clavicles, severe in trauterine growth retardation, and oligohydramnios. This syndrome differs f rom that of Ivemark and related syndromes due to lack of liver involvement, After these two sibs, this consanguineous family had a third child and an early prenatal diagnosis of pancreatic and dysplastic renal cysts was made in the 19.5-week-old fetus. The last case supports the genetic hypothesis. (C) 2000 Wiley-Liss, Inc.