MR imaging of the pituitary gland in children and young adults with congenital combined pituitary hormone deficiency associated with PROPI mutations

Authors
Fofanova, O Takamura, N Kinoshita, E Vorontsov, A Vladimirova, V Dedov, I Peterkova, V Yamashita, S
Citation
O. Fofanova et al., MR imaging of the pituitary gland in children and young adults with congenital combined pituitary hormone deficiency associated with PROPI mutations, AM J ROENTG, 174(2), 2000, pp. 555-559
Citations number
12
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
AMERICAN JOURNAL OF ROENTGENOLOGY
ISSN journal
0361803X → ACNP
Volume
174
Issue
2
Year of publication
2000
Pages
555 - 559
Database
ISI
SICI code
0361-803X(200002)174:2<555:MIOTPG>2.0.ZU;2-L
Abstract
OBJECTIVE. The aim of this study was to clarify the relationship between mo rphologic changes of the pituitary gland and the genotype of Prophet of Pit -1 (PROP1), a newly discovered gene responsible for congenital combined pit uitary hormone deficiency, in a series of eight humans with this disorder. CONCLUSION. Congenital hypoplasia of the anterior pituitary gland is the mo st common MR imaging finding in patients with combined pituitary hormone de ficiency. Our findings suggest a crucial role for PROP1 in pituitary organo genesis as well as anterior pituitary cell differentiation.