Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model

BACKGROUND: The selectin glycoproteins are involved in the pathogenesis of renal ischemiare-perfusion injury, We investigated the ability of glycyrrhi zin, a known selectin inhibitor, to attenuate renal ischemia-reperfusion in jury. METHODS: Eighteen New Zealand white rabbits underwent midline laparotomy wi th renal artery cross-clamping, After 30 minutes of reperfusion, group 1 (c ontrol, n = 10) animals received a saline infusion, while group 2 (GLY, n = 8) animals received a glycyrrhizin infusion. Renal function was compared b etween the two groups after 72 hours of reperfusion. A t test was utilized, with alpha set at P <0.05. RESULTS: Group 1 and group 2 animals had similar baseline renal function. H owever, after 72 hours of reperfusion, group 1 animals had a significantly higher mean blood urea nitrogen creatinine ratio than group 2 animals (P <0 .01), indicating preserved renal function in rabbits treated with glycyrrhi zin. CONCLUSIONS: Selectin blockade using glycyrrhizin attenuates renal ischemia -reperfusion injury when given 30 minutes after the onset of reperfusion in a rabbit model, Am J Surg. 1999;178: 573-576. (C) 1999 by Excerpta Medica, Inc.