EFFECTS OF ENALAPRIL ON LEFT-VENTRICULAR FUNCTION AND EXERCISE PERFORMANCE AFTER A FIRST ACUTE MYOCARDIAL-INFARCTION

Authors
GARRI FS MARTINEZ JGM ESMORIS LG BARTOLOME LA GARCIA GC CUSI LS AUNON AA GOMEZ MRG FERRAGUT LM MASANES SP SZESCLIELINSKI L BRUGUERA J SERRADEL RS CAPDEVILA MC LOPEZ FN BOSCH X BATLLE AF GALVEZ CP VELARDE MAS TORRENT FLD URENA CG BELSUE FV SANCHEZ MPA PITA AM MAYOR JLB NAVARRO CR BEIRAS AC RODRIGUEZ JMV MELLADO OB LOPEZ MA VILARDEBO CP DECASTROVIEJO EVR MARTINAMBROSIO ES GARCIA MAR GARIA AM CARRENO DL MARTINEZ JV RIESCO CD MARCO CL MANCEBO FJC DELACALZADA CS SANCHEZ MAG CALLE G PAJUELO CG MARTINEZ JP JADRAQUE LM MAQUEDA IG PULPON LA ALONSO A ARTAZA M MAICAS C BULLON FS DEPRADO AP DELCAN JL CARDIEL EA LANZONI M DETORRES FM MADERO GF CALIANI JSE GONZALEZ E DETERESA E ABIZANDA JAR NIETO JS CHAVARRI MV ALBEROLA AG LLOSA AC LAMBERT R BUSTINZA ICM FERNANDEZACEITUNO AM LATASA I LOPEZ DV BENITEZ ID LAGE ED REYERO JB NAVASCUES IM LUENGO CM BALLESTER FN BAZA LC JIMENEZ AA CASTILLO ASS LOMBARDIA AL IRAOLA RQ MARQUEZ JMG JUDEZ MC DELAPENA MG VAZQUEZ FF DIEGUEZ MAB PEREZ MP LAMELA AV HERNANDEZ JMC GARCIAARANDA VL GARCIA RV VALDERRAMA JC TORRES LP MARTINEZ AM BURGOS J MORALES AC TRUJILLO DD ALMEIDA JL PADRON AL RODRIGUEZ FM RAMI JAD ERRAZTI IE HERRERO JVV BOSCA JL FERNANDEZ FA MERINO VL ESCORIHUELA AL SANCHEZ FC BEINER JAN CAL HB COMESANA VC GOMEZ AMA MORA MCB AZCARGORTA IC BURRIEL AA PERALTA LP VAL FC BENITO GM MERCHANTE P MONTERO IF CASANOVAS JA LIGORIT AD FERREIRA A CARDIEL EA BEIRAS AC MONTERO IF SANCHEZ MAG ESTEBAN JG LOPEZ FN RAMI JAV ZAMORANO MAS GUALLAR E MARTINMORENO JM
Citation
Fs. Garri et al., EFFECTS OF ENALAPRIL ON LEFT-VENTRICULAR FUNCTION AND EXERCISE PERFORMANCE AFTER A FIRST ACUTE MYOCARDIAL-INFARCTION, International journal of cardiology, 59(3), 1997, pp. 257-265
Citations number
26
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
International journal of cardiology → ACNP
ISSN journal
01675273
Volume
59
Issue
3
Year of publication
1997
Pages
257 - 265
Database
ISI
SICI code
0167-5273(1997)59:3<257:EOEOLF>2.0.ZU;2-H
Abstract
Aims: To study the effects of early use of enalapril on left ventricul ar function and exercise capacity after a first acute myocardial infar ction, 356 patients without overt signs of congestive heart failure we re randomly allocated to receive placebo or enalapril between days 7 a nd 14 after a first myocardial infarction. The study was conducted dou ble-blind in 40 hospitals throughout Spain. Methods and results: At ba seline and after 26 weeks of follow-up exercise stress tests, Doppler- echocardiograms and isotopic ventriculography were performed in study participants. At the end of follow-up, patients in the enalapril group had lower end-systolic volume compared to those in the placebo group (55 vs. 62 ml, P=0.05). No difference in exercise capacity was evident between both groups. Conclusion: The present study shows that enalapr il therapy administered between 7 and 14 days after a first acute myoc ardial infarction decreases end-systolic volume and may inhibit the re modeling process of the left ventricle. (C) 1997 Elsevier Science Irel and Ltd.