Near-tetraploid minimally differentiated acute myeloid leukemia with extensive erythrophagocytosis by leukemic blasts

Numerical change of chromosomes is common in acute myeloid leukemia (AML). However, a chromosome number as high as near-tetraploidy is very rare, espe cially in minimally differentiated AML (AML-MO), Erythrophagocytosis by rea ctive or malignant histiocytes is common in malignant hematological disease s: however, erythrophagocytosis by leukemic blasts is also very rare, espec ially in AML-MO, We report here the first case of AML-ILIO with both of the se unique characteristics: a near-tetraploid karyotype and erythrophagocyto sis by leukemic blasts.