Hepatic failure in a patient taking rosiglitazone

Background: Rosiglitazone maleate is the second approved oral hypoglycemic agent of the thiazolidinedione class. The first, troglitazone, has been ass ociated with liver failure, occasionally resulting in liver transplantation or death. There have been no reports to date of rosiglitazone-associated e levations in the alanine aminotransferase level or hepatotoxicity. Objective: To report the clinical characteristics of liver failure developi ng in a patient receiving rosiglitazone. Design: Case report. Setting: University hospital. Patient: 69-year-old man taking rosiglitazone, 4 mg/d. Intervention: Discontinuation of rosiglitazone therapy and treatment with l actulose, vitamin K, fresh frozen plasma, ventilatory assistance, and inten sive care unit support. Measurements: Blood test monitoring, including toxicology screening, liver function tests, coagulation studies, serum chemistries, and complete blood counts. Results: After 21 days of rosiglitazone therapy, hepatic failure developed. Other causes of hepatic failure, such as viruses and toxins, were excluded , although it is possible that congestive heart failure was also a causativ e factor. The patient recovered fully with supportive care. Conclusion: Rosiglitazone may be associated with hepatic failure.